I've got an old machine. I try to use uncompressed or lightly compressed files. If I use even the cineform codec my machine chokes. One file I compared recently showed Matrox Mpeg2 I-frame HD and Cineform. The Cineform was half the size but the Matrox was easier to cope with. See, when you edit with a compressed format, the processor has to decode more in order make a frame for you to edit around. A less compressed format takes up more space, but it takes less processor resources to decode and be used for frame by frame editing.
Another thing is it is nearly impossible for me to edit high resolution. I always reduce the 1920x1080 to 1280x720. The 1920x1080 is 3 times as big as the 1280x720, if I recall correctly.